From the Australian Settlement to Microeconomic Reform: the Change in Twentieth Century Policy Regimes

This paper outlines and discusses explanations of the substantial shift in the economic policy regime in Australia. The first regime held from federation through the 1970s. It focused on extensive development, through the attraction and retention of selected immigrants by a set of mutually-supportive policies centered on trade protection. The second strategy, of recent vintage, concentrates more on intensive development and, in contrast with the earlier, relies on economic competition, rather than attempting to suppress it. Similar shifts in policy regimes have occurred in other countries, but with different timing and character. In the Australian case, there was bi-partisan support for the claims that liberalization was a desirable response to the changed external economic environment.

Naturalistic Sentence Comprehension in the Brain

The cognitive neuroscience of language relies largely on controlled experiments that are different from the everyday situations in which we use language. This review describes an approach that studies specific aspects of sentence comprehension in the brain using data collected while participants perform an everyday task, such as listening to a story. The approach uses ‘neuro‐computational’ models that are based on linguistic and psycholinguistic theories. These models quantify how a specific computation, such as identifying a syntactic constituent, might be carried out by a neural circuit word‐by‐word. Model predictions are tested for their statistical fit with measured brain data. The paper discusses three applications of this approach: (i) to probe the location and timing of linguistic processing in the brain without requiring unnatural tasks and stimuli, (ii) to test theoretical hypotheses by comparing the fits of different models to naturalistic data, and (iii) to study neural mechanisms for language processing in populations that are poorly served by traditional methods.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133583/1/lnc312198.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133583/2/lnc312198_am.pd

Towards validation of a new computerised test of goal neglect: preliminary evidence from clinical and neuroimaging pilot studies

Objective: Goal neglect is a significant problem following brain injury, and is a target for rehabilitation. It is not yet known how neural activation might change to reflect rehabilitation gains. We developed a computerised multiple elements test (CMET), suitable for use in neuroimaging paradigms. Design: Pilot correlational study and event-related fMRI study. Methods: In Study 1, 18 adults with acquired brain injury were assessed using the CMET, other tests of goal neglect (Hotel Test; Modified Six Elements Test) and tests of reasoning. In Study 2, 12 healthy adults underwent fMRI, during which the CMET was administered under two conditions: self-generated switching and experimenter-prompted switching. Results: Among the clinical sample, CMET performance was positively correlated with both the Hotel Test (r = 0.675, p = 0.003) and the Modified Six Elements Test (r = 0.568, p = 0.014), but not with other clinical or demographic measures. In the healthy sample, fMRI demonstrated significant activation in rostro-lateral prefrontal cortex in the self-generated condition compared with the prompted condition (peak 40, 44, 4; ZE = 4.25, p(FWEcorr) = 0.026). Conclusions: These pilot studies provide preliminary evidence towards the validation of the CMET as a measure of goal neglect. Future studies will aim to further establish its psychometric properties, and determine optimum pre- and post-rehabilitation fMRI paradigms

Fiscal Equity In Federal Systems

This paper examines the normative foundations of fiscal equalization an issue handled, apparently decisively, in a classic paper by James Buchanan (1950). Contrary to Buchanan's claims, we argue that fiscal equalization requires extremely strong value judgements at least in the case where fiscal differences arise from the interaction of public goods provision under different population size effectively committing one to a Rawlsian maximin rule. Much weaker forms of the 'social welfare function' in this public goods case will generate the requirement that private consumption levels be equalized, but specifically not public consumption levels in which sense private goods equalization seems normatively weaker than public goods equalization, If this is so, the hope of justifying federal fiscal equalization on the basis of relatively uncontroversial individualistic norms seems illusory

Effectiveness of anonymised information sharing and use in health service, police, and local government partnership for preventing violence related injury: experimental study and time series analysis

Objective: To evaluate the effectiveness of anonymised information sharing to prevent injury related to violence. Design: Experimental study and time series analysis of a prototype community partnership between the health service, police, and local government partners designed to prevent violence. Setting: Cardiff, Wales, and 14 comparison cities designated "most similar" by the Home Office in England and Wales. Intervention After a 33 month development period, anonymised data relevant to violence prevention (precise violence location, time, days, and weapons) from patients attending emergency departments in Cardiff and reporting injury from violence were shared over 51 months with police and local authority partners and used to target resources for violence prevention. Main outcome measures: Health service records of hospital admissions related to violence and police records of woundings and less serious assaults in Cardiff and other cities after adjustment for potential confounders. Results: Information sharing and use were associated with a substantial and significant reduction in hospital admissions related to violence. In the intervention city (Cardiff) rates fell from seven to five a month per 100 000 population compared with an increase from five to eight in comparison cities (adjusted incidence rate ratio 0.58, 95% confidence interval 0.49 to 0.69). Average rate of woundings recorded by the police changed from 54 to 82 a month per 100 000 population in Cardiff compared with an increase from 54 to 114 in comparison cities (adjusted incidence rate ratio 0.68, 0.61 to 0.75). There was a significant increase in less serious assaults recorded by the police, from 15 to 20 a month per 100 000 population in Cardiff compared with a decrease from 42 to 33 in comparison cities (adjusted incidence rate ratio 1.38, 1.13 to 1.70). Conclusion: An information sharing partnership between health services, police, and local government in Cardiff, Wales, altered policing and other strategies to prevent violence based on information collected from patients treated in emergency departments after injury sustained in violence. This intervention led to a significant reduction in violent injury and was associated with an increase in police recording of minor assaults in Cardiff compared with similar cities in England and Wales where this intervention was not implemented

How do Listeners Form Grammatical Expectations to African American Language?

Ideologies about standard language in the United States often posit Mainstream U.S. English (MUSE) as a morally superior variety (Hill 2008). Previous research has shown that this kind of hierarchical treatment of language varieties leads to negative perceptions of non-standard languages, which in turn makes them stigmatized, and ultimately perpetuates dialect discrimination. This kind of discrimination results in the mistreatment of users of non-standard varieties, which negatively affects the way those speakers can move through the U.S. context (Rickford 1999, Eckert and Rickford 2001, Schilling 2004, Rickford and King 2016). This study investigates how listeners alter their linguistic expectations when hearing speakers of standard and non-standard varieties of English through an Electroencephalography (EEG) experiment. We probe how social information influences syntactic processing to see if and when speakers of a standard dialect, MUSE, form grammatical expectations when processing MUSE and African American Language (AAL). Looking at online processing helps us better understand whether listeners have specific knowledge of the dialect that is not their own (dialect-specific hypothesis), or whether listeners more generally reduce expectations across the board when listening to a dialect or variant that they themselves do not speak (dialect non-specific hypothesis). In order to test the interaction between language variety and auxiliary usage, experimental sentences were constructed in order to reflect a variant that is grammatical in MUSE, a variant that is grammatical uniquely to AAL, and a grammatical variant that is ungrammatical in all varieties of English. The experimental stimuli from a bidialectal Midwestern black speaker of both MUSE and AAL, yielding a within subject 2 (language varieties) by 3 (grammatical features) design. The results do not cleanly favor the dialect-specific nor the dialect non-specific hypothesis. Rather, the evidence points a nuanced version of a mixture of both hypotheses. Through analysis of American English dialects, this work contributes to further understanding of how social information interfaces with online processing, and expectations that may be formed depending on the perceived identity of a voice. The impact of this work is paramount, as perceptions of stigmatized language varieties can lead to dialect discrimination that negatively affects the way those speakers are treated (Rickford 1999, Purnell, Baugh, Idsardi 1999, Eckert and Rickford 2001, Schilling 2004, Rickford and King 2016

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development

In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnidarian model to study the origins of TLR signaling because its genome encodes a single TLR and homologs of many downstream signaling components, including the NF-κB pathway. We have characterized the single N. vectensis TLR (Nv-TLR) and demonstrated that it can activate canonical NF-κB signaling in human cells. Furthermore, we show that the intracellular Toll/IL-1 receptor (TIR) domain of Nv-TLR can interact with the human TLR adapter proteins MAL and MYD88. We demonstrate that the coral pathogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated V. coralliilyticus and bacterial flagellin can activate a reconstituted Nv-TLR–to–NF-κB pathway in human cells. By immunostaining of anemones, we show that Nv-TLR is expressed in a subset of cnidocytes and that many of these Nv-TLR–expressing cells also express Nv-NF-κB. Additionally, the nematosome, which is a Nematostella-specific multicellular structure, expresses Nv-TLR and many innate immune pathway homologs and can engulf V. coralliilyticus. Morpholino knockdown indicates that Nv-TLR also has an essential role during early embryonic development. Our characterization of this primitive TLR and identification of a bacterial pathogen for N. vectensis reveal ancient TLR functions and provide a model for studying the molecular basis of cnidarian disease and immunity.IOS-1354935 - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); 1262934 - National Science Foundation (NSF); 2014-BSP - Arnold and Mabel Beckman Foundatio